Conditionally Active CD3 & CD2 Costimulatory T-Cell Engagers for Solid- Tumor Indications

  • Conditional CD3 activation via hidden CD3 binder in TROY-Ig scaffold mitigates cytokine release
  • CD2 costimulation and CD58 adhesion lowers the threshold for CD3 activation in T-cells
  • CD2 costimulation and conditional CD3 activation TROY-Ig scaffold enables increased anti-tumor efficacy in solid tumor microenvironment