Uncover Mechanism, Diversify Design, Expand Indication

Groundbreaking data from Akeso and Summit Therapeutics has shown that ivonescimab reduced the risk of disease progression by 49% compared to Keytruda in NSCLC, redefining the strategic landscape for bispecific development. As a result, bispecifics continue to deliver real-world clinical success, from PD-1xVEGF to CD3-based TCEs. However, drug developers now face new challenges in translating this progress into best-in-class therapies.

While bispecific developers work to understand the mechanistic basis of this target combination, the industry strives to find the next best target. As development diversifies beyond oncology into autoimmune diseases and T-Cell Engagers, 2025 stands as a pivotal year to shape current and future bispecific development.

The 16th World Bispecific Summit returns as the industry’s longest-running and most comprehensive event, devoted exclusively to the design, development, and translation of bispecific and multispecific therapeutics. Bringing together the industry leaders, making it all happen, including Regeneron, Sanofi, Novartis, Immunocore, Zymeworks, and more to share actionable insights and real-world case studies. Attendees will gain strategies to design more effective bispecifics, select smarter target pairings, streamline manufacturability, and mitigate safety risks - accelerating the path from discovery to clinic.