Pre-Conference Seminar Day

The first half of the seminar day explores how cutting-edge technologies and design strategies are reshaping the molecular architecture and functional engineering of bi- and multispecifics.

Attendees will gain insights into high-throughput approaches such as protein trans-splicing for combinatorial multispecific generation, alongside AI-guided design of next-generation T-cell engagers to optimize specificity and efficacy.

Grounded in real-world case studies, these sessions connect early molecular design decisions with downstream functional performance, equipping attendees with practical, data-driven insights to inform more effective multispecific development.

• Protein trans-splicing is a novel method for the generation of multispecific antibodies
• Spliced antibodies can be made in a wide array of formats and recapitulate the biophysical and functional properties of conventionally produced molecules
• This technology enables the discovery of binder pairs with unique biology by facilitating the high-throughput production and screening of combinatorial libraries of multispecific antibodies

• Exploring why new TCE designs such as dual targeting or avidity-based formats are required to overcome the challenges to TCE efficacy posed by solid tumors
• Building a deeper understanding of the affinity and epitope requirements that maximize tumor selectivity which will be critical to unlock the potential of dual targeting TCEs
• AI integration is profoundly impacting therapeutic discovery, enabling delivery of optimized candidates at breakthrough speed

If your solution is advancing molecular architecture and functional engineering of bispecifics and multispecifics, this dedicated slot enables you to showcase your approach through data-driven insights and real-world case studies, equipping delegates with practical scientific learnings on how cutting-edge design strategies are tackling key development challenges. Interested in partnering with us? Contact sponsor@hansonwade.com to learn how you can secure this speaking slot to showcase your expertise.

• Roundtable discussions are designed to be interactive, deep dives where attendees break into smaller groups to explore a focused topic through candid, peer-led conversation. Each group will exchange experiences, challenges, and practical insights before reconvening to share key takeaways with the wider audience and with the conversation being facilitated by our seminar day leaders.

The second half of the seminar day investigates how formulation and CMC strategies informed by FDA-approved bispecific and multispecific antibodies can accelerate development and derisk downstream challenges.

Attendees will gain insights into defining optimal formulation design space, mitigating aggregation risks, and applying stability-first approaches to streamline CMC readiness. Complementing this, the session will examine potency assay development for complex biologics, highlighting analytical challenges, assay robustness, and how data-driven insights can guide formulation and process decisions, equipping attendees with practical lessons for more efficient, developable multispecific programs.

• Leveraging insights from FDA-approved Bispecific and Mult Specific Antibodies as a reference to define realistic pH ranges, protein concentrations, excipients and formulation design space from the outset
• Proactively understanding the aggregation risks and atypical stability profiles of complex formats to better anticipate and mitigate key developability challenges
• Applying a stability-first formulation strategy to support faster development by reducing the need for late-stage reformulation and streamlining overall CMC readiness

• Strategies for designing and optimizing cell based potency assays for complex multi target biologics
• Case studies highlighting analytical challenges, assay robustness, and orthogonal approaches
• Lessons learned on how analytical data can inform formulation and process development decisions

• Accelerating biologics CMC timelines through strategic, risk-based development approaches
• Balancing purification efficiency, manufacturability, and product variant control
• De-risking late-stage development through early product and process understanding

If your solution is advancing molecular architecture and functional engineering of bispecifics and multispecifics, this dedicated slot enables you to showcase your approach through data-driven insights and real-world case studies, equipping delegates with practical scientific learnings on how cutting-edge design strategies are tackling key development challenges. Interested in partnering with us? Contact sponsor@hansonwade.com to learn how you can secure this speaking slot to showcase your expertise.

• Roundtable discussions are designed to be interactive, discursive deep dives where delegates break into smaller groups to explore a focused topic through candid, peer-led conversation. Each group will exchange experiences, challenges, and practical insights before reconvening to share key takeaways with the wider audience and with the conversation being facilitated by our seminar day leaders.