September 22-24, 2015 | Boston, MA

Day One

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Wednesday September 23rd

Chair’s Opening Remarks

KEYNOTE: Blinatumomab: From Bench To Market

KEYNOTE: Propel Progress Of Translational Research And Reduce Time To Clinic

Overcome Challenges Of Transporting Antibodies Across The Blood-Brain Barrier

Speed Networking & Morning Refreshments

DISCOVERY STREAM: Broadening The Target Pool For Bispecifics

- Overcoming Challenges Of Effectively Validating Multispecific Targets

- Validation Of Synergistically Effective Targets

- Examining Approaches To Antigen Selection & Bispecific Screening Which Maximize On Target Activity



DEVELOPMENT STREAM: Improving Preclinical Development

- Anti-CD20/CD3 T-cell Dependent Bispecific Antibody (TDB) As Potential Therapy For B-cell Malignancies

- Explore The Next Generation Of Cell Based Assays

- Discover Effective Humanized Preclinical Models

Lunch & Networking

DISCOVERY STREAM: Optimization Of Bispecifics

- Parameters To Take Into Consideration When Developing A Dual-Targeting Antibody

- Evidenced Based Approaches To Overcoming Development Challenges

- Effectively Extend The Half Life Of Small Fragments

- Engineering & Optimization of Drug-Like Properties Beyond Efficacy To Create More Stable Constructs

DEVELOPMENT STREAM: Analyzing & Mitigating Toxicity

- Current Challenges & Opportunities In Toxicity Assessment Of Multispecific Biologics

- Translational Strategy For Bispecifics: From Preclinical PK To Clinical PKPD

- Improve Predictability Of Preclinical Research For Bispecific Scaffolds

- Identifying & Validating Clinically Relevant Biomarkers

Afternoon Refreshments & Networking

Maximize Developability & Manufacturability of Bispecifics

Ensure Candidates Have Superior Manufacturing Attributes & Can Be Successfully Formulated

Effectively Scale-Up From Bench To Clinical Manufacturing

Significantly Improve Bispecific Yield Production

Effectively Purify Multispecfic Formats & Achieve Efficient Removal Of Aggregates

Chair’s Stream Summaries & Chair’s Closing Remarks

Drinks Reception & Networking

After the formal presentations have finished, the networking carries on. The Drinks Reception is an informal part of the conference agenda, allowing speakers and attendees to connect with their peers after the conference in a relaxed atmosphere and continue to forge new relationships with other bispecific experts.