Mohamed-Reda Benmebarek
CRTA Postdoctoral Fellow National Cancer Institute
Seminars
Tuesday 9th September 2025
Investigating How Simultaneous Targeting of VEGF, PD-L1 & CTLA4 Reshapes the Tumor Microenvironment to Outline Modes of Action & Safety Considerations For Your Bispecifics
10:00 am
- Exploring the immunomodulatory effects of VEGF targeting that synergize with known antiangiogenic effects and inform safety considerations for its targeting
- Dissecting the multimodal mechanism induced by multitargeting strategy to understand how simultaneous targeting of axes present in diverse cell types in the tumor microenvironment can alter the cytokine landscape and ultimately rewire key effector and suppressive cell types: considerations of efficacy and safety
- Assessing the practicality of using bispecifics for membrane-bound and soluble targets: Exploring the potential benefits and challenges of how multitargeting strategies can best tackle the underlying immunobiology
