Supercharging T Cell Engagers: Expanding Immune Activation Beyond Traditional Bispecific Design
- Unlocking innate immunity by introducing a novel approach to load innate immune cells with a T cell engager receptor, enabling engagement by existing T cell engagers in vivo
- From T cell engager to multi-cell engager: Enhancing approved T cell engager therapies to recruit both adaptive and innate immune arms for broader, more durable anti-tumor responses
- Thinking beyond traditional Bispecifics by demonstrating how existing T cell engages can be repurposed to drive wider immune activation without altering their structure or target affinity