Immuno-STATs: a Novel Class of T Cell Engagers for B Cell Depletion in Autoimmune Diseases
Time: 12:30 pm
day: Day Two
Details:
- Immuno-STATs are a new class of TCR-selective engagers for selective modulation of disease-relevant T cells
- CUE-100 series Immuno-STATs have been clinically validated in oncology, and have demonstrated significant increase in efficacy (ORR and mPFS) vs SoC
- Here we describe the CUE-500 series, which can re-direct the protective virus-specific T cells (VSTs) to deplete B cells, hence providing unprecedented selectivity for exploiting the killing potential of VSTs, and positions this class of biologics as an attractive alternative for CAR-T approaches
